Wheat Grass References

Wheat Grass References

There is a great deal of information regarding the role wheat grass has in maintaining health and preventing disease.  The following is a growing list of wheat grass resources, references and quotes by people and organizations.

1.  Wheat Grass Juice in the Treatment of Active Distal Ulcerative Colitis: A Randomized Double-blind Placebo-controlled Trial

Authors: Ben-Arye E.; Goldin E.; Wengrower D.; Stamper A.; Kohn R.; Berry E.

Source: Scandinavian Journal of Gastroenterology, Volume 37, Number 4, 1 April 2002 , pp. 444-449

Publisher: Informa Healthcare

The study: Twenty-one patients completed the study, and full information was available on 19 of them. Treatment with wheat grass juice was associated with significant reductions in the overall disease activity index (P = 0.031) and in the severity of rectal bleeding (P = 0.025). No serious side effects were found. Conclusion: Fresh extract of wheatgrass juice appeared effective and safe as a single or adjuvant treatment of active Distal Ulcerative Colitis.

2. Wheat Grass Juice Reduces Transfusion Requirement in Patients with Thalassemia Major: A Pilot Study (Opens as .pdf)

Authors: R.K. Marwaha, Deepak Bansal, Siftinder Kaur and Amita Trehan

Source: Division of Pediatric Hematology-Oncology, Department of Pediatrics, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research,
Chandigarh 160 012, India.

The Study: Randomly selected patients with transfusion dependent b-thalassemia, enrolled in the thalassemia unit of the Advanced Pediatrics Center were recruited for the study. About 100ml of freshly extracted wheat grass juice was consumed daily. Patients had to be on wheat grass juice for at least one year, after the neutral period (6 months), for inclusion in the analysis. Conclusion: Consumption of wheat grass juice was found to have beneficial effect on the transfusion requirements in 50% of patients in this pilot study.

3. CN Lai, B Dabney and C Shaw (1978) Inhibition of in vitro metabolic activation of carcinogens by wheat sprout extracts. Nutrition and Cancer, 1 (1):27-30

4. CN Lai (1979) Chlorophyll: The active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro. Nutrition and Cancer, 1 (3):19-21

5. Smith & Livingston. 1943. Chlorophyll. An experimental study of its water soluble derivatives in wound healing
Wound healing involves an inflammatory (exudative) phase and a proliferative tissue growth and repair phase that presumably involves growth stimulating factors. This study tested various water soluble chlorophyll preparations and other agents including vitamin ointments and sulfathiazole on wounds created by excising portions of skin from rats, guinea pigs, rabbits and dogs. Response in rate of healing tended to be greater for chlorophyll than with other agents tested (the data is summarized in several tables not reproducible here).‘On the basis of these observations it is suggested that chlorophyll preparations should be used much more extensively in the treatment of wounds and burns.’

 6. Kohler et al. 1939. The grass juice factor
The grass juice ‘factor’ was precipitated from grass juice or dehydrated grass by using acetone. It is necessary for the normal growth of rats and guinea pigs. Guinea pigs fed a rationed diet died in 3 to 10 weeks but when dehydrated grass was included in the same diet they grew normally.

7. Randle, Sober, Kohler. 1940. The distribution of the ‘grass juice factor’ in plant and animal materials.
Guinea pigs were fed on winter milk plus various supplements. Those fed on a supplement rich in the grass juice factor (rye grass) showed strong growth. Various plants were assayed for the grass juice factor. Based on average weight gain in guinea pigs the best sources of this growth promoting substance were dehydrated cereal grass (cerophyl), rye grass, young white clover, peas, pea shells, cabbage, spinach. Cereal grasses are an excellent source of the factor but the amount present varies with the age of the plant

8. Kohler. 1944. The effect of stage of growth on the chemistry of the grasses.
Younger grass tends to be richer in protein, soluble carbohydrates, carotene, vitamin C, thiamine and riboflavin. Using oats, Kohler found that several of the vitamins, protein, crude fat and chlorophyll reached peak concentrations at or near the jointing stage, hence the nutritive value of grass is likely to be optimal at this point.

9. Kohler et al. 1936. Growth stimulating properties of grass juice
Growth of rats is greater on a diet of summer milk than winter milk. When grass juice was added to the winter milk diet, growth increased from 2 to 4 grams a day. It was concluded that there are important water-soluble substances in the juice that affect the nutritive value of summer milk.

10. Peryt et al. 1992. Mechanism of antimutagenicity of wheat sprout extracts
A supernatant extract from wheat grass reduced the production of carcinogenic aromatic hydrocarbon (benzopyrene) derivatives. Inhibition of benzopyrene mutagenicity with non-chlorophyll containing wheat sprout extract suggests that chlorophyll is not the main compound responsible.

11. Ben-Ayre et al. 2002. Wheat grass juice in the treatment of active distal ulcerative colitis
A randomized, double-blind, placebo trial was undertaken with 23 patients in Israel . Treatment with wheatgrass (100 cc a day for one month) reduced the overall disease activity and severity of rectal bleeding in patients with active distal ulcerative colitis. No serious side effects were found. The authors concluded that ‘wheat grass juice appeared effective and safe as a single or adjuvant treatment of active distal ulcerative colitis’.

12. George S. Bailey, Ph.D. Oregon State University – Distinguished Professor Chlorophylls and Cancer Prevention
“Chlorophyllin had an ability to bind or “sandwich” certain classes of chemical mutagens and carcinogens. These included polyaromatic hydrocarbons found in tobacco smoke, some heterocyclic amines (”cooked meat mutagens”), and aflatoxin chemicals suspected or known to cause human lung, colon, or liver cancer,. .”

13. A study conducted by researchers at the Johns Hopkins Bloomberg School of Public Health shows that taking chlorophyllin greatly reduces the levels of aflatoxin-DNA damage byproducts in the body, which are indicators of exposure to carcinogenic aflatoxins and increased risk of liver cancer. Chlorophyllin is a derivative of chlorophyll and is used as an over-the-counter diet supplement and as a food colorant. The results appear in the November 27, 2001 edition of Proceedings of the National Academy of Sciences. “Our study shows that taking Chlorophyllin three times a day reduced the amounts of aflatoxin-DNA damage by 55 percent, compared with taking a placebo,” says Thomas Kensler, PhD.

14.Chlorophyllin reduces risk of breast cancer. In human breast cell studies, chlorophyllin was one of the most effective compounds protecting against DNA adduct formation. Chlorophyllin inhibited adduct formation 65% at 30 micromolar concentrations, and it was also a very effective inhibitor at 15 micromoles, a level obtainable in vivo in the tissues of humans (Smith et al. 2001).

15. In vitro studies with chlorophyllin show it to be an inhibitor of the cytochrome P-450 liver enzymes (Tachino et al. 1994). All in vivo [whole animal] studies where cytochrome P-450 enzyme activity is reduced resulted in lower cancer rates and longer lifespan (Guengerich et al. 1991). In Stage 2 liver detoxification, enzymes called glutathione transferases cause glutathione to react with the carcinogens formed from cytochrome P-450 activity to produce harmless additional products, but this process is not very efficient (Finch et al. 1997). Chlorophyllin, however, makes this conversion more efficient by lowering cytochrome P-450 enzyme activity in the first place and by reacting with carcinogens to produce harmless complexes, just as the glutathione transferases do. Thus, chlorophyllin is not an inducer of glutathione transferases but mimics glutathione transferase activity.

16. “The risk of liver, colon, stomach, and lung cancer which include the leading causes of cancer death in the US and the world, may easily be cut in half by appropriate daily intake of simple, safe, inexpensive chlorophyll derivatives.” Dr. Richard C. Heimsch

17. Wheatgrass Juice Helps to Reduce Chemotherapy Side Effects of Breast Cancer Patients

“In this prospective matched control study, 60 patients with breast carcinoma on chemotherapy were enrolled and assigned to an intervention or control arm. Those in the intervention arm (A) were given 60 cc of wheat grass juice orally daily during the first three cycles of chemotherapy, while those in the control arm (B) received only regular supportive therapy.”

Conclusion: It was found that Wheat Grass Juice taken during FAC chemotherapy may reduce myelotoxicity, dose reductions, and need for GCSF support, without diminishing efficacy of chemotherapy.

Source: Bar-Sela Gil, Tsalic Medy, Fried Getta, Goldberg Hadassah. Wheat Grass Juice May Improve Hematological Toxicity Related to Chemotherapy in Breast Cancer Patients: A Pilot Study. Nutrition and Cancer 2007, Vol. 58, No. 1, Pages 43-48. Division of Oncology, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

18. The effect of wheat grass juice in supportive care of terminally ill cancer patients

Background: During a period from January 2003 to December 2005, 400 solid organ cancer patients were selected in the palliative care unit of Netaji Subhash Chandra Bose Cancer Research Institute (India) to see the effect of wheat grass haemoglobin levels, serum proteins & performance status.

Conclusion: It was concluded that wheat grass juice is an effective alternative (natural) for blood transfusion. Its use in terminally ill cancer patients should be encouraged.

Source: Dey S., Sarkar R., Ghosh P., Khatun R., Ghorai K., Choudhury R., Ahmed R., Gupta, P., Mukhopadhyay S., Mukhopadhyay A. Effect of Wheat Grass Juice in Supportive Care of Terminally Ill Cancer Patients — A Tertiary Cancer Centre Experience from India. Journal of Clinical Oncology 2006 ASCO Meeting Proceedings Part I. Vol 24, No. 18s (June 20 Supplement), 2006: 8634.  

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